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Prolonged High Protein or High Fat Diet Is Not Safe For You

too-much-protein can be harmfulIn preparing a healthy diet meal plan, it is common that most of the recipes or even instructions for anti aging fat loss would recommend having more proteins and high beneficial fat. Are you even aware that prolonged high protein or high fat diet is risky? There are certain risks involved when you choose to sustain your body with a high protein diet for longer periods. High protein diets are protein packed foods that can keep you satiated and satisfied. The high protein diet, especially those that restricts carbohydrates in an extended time can result in an unwanted nutritional deficiencies or insufficient fiber, increase your risk of heart disease, and can worsen your problem relating to kidney function and in eliminating waste.


What makes it unsafe?

For obesity weight management, high protein diets often restrict carbohydrates so much that you end up in nutritional deficiencies, which causes constipation and diverticulitis. Some include and promotes red meat and dairy products that increases your risk of cardiovascular disease. This may lead to kidney dysfunction because your body may have difficulties eliminating all the waste products of protein metabolism.



While bodybuilders and nutritionists highly recommend a high protein diet for building tissues such as the lean muscle mass, an extreme protein intake (that is in excess of 200 g per day) and an inadequate intake of carbohydrates can lead to a metabolic disturbance or rabbit starvation.


Some high protein, very low carbohydrate diet for weight loss are designed to induce ketosis. Ketone bodies are formed from fatty acids. An increase of the level of your circulating ketones can disturb the acid balance of your body and cause metabolic acidosis. Deleterious consequences of even mild acidosis are low blood phosphate levels, increased risk of osteoporosis, increased propensity to kidney stones, and resorption of calcium from the bones.


rabbit starvation weight lossThere has been considerable debate that argues about the safety and the validity of increasing the protein intake to lose weight and to build muscles. The advertisements and promotion taken by the popular media to consume diets high in protein lack scientific data about its safety.


The key issue is the rate your GI tract can absorb amino acids from dietary proteins. In addition, you need to consider the liver’s capacity to deaminate proteins and produce urea for the excretion of the excess nitrogen.


High protein diets may exceed the liver’s capacity to convert the excess nitrogen to urea. Some noted dangers of excessive protein (constitute about 35% of the total energy intake) are diarrhea, hyperammonemia, hyperinsulinemia nausea, and even death (rabbit starvation syndrome).


Ammonia is neurotoxic. Marked brain damage has been noted in cases of failure to make urea via the urea cycle or to eliminate urea through the kidneys. The result of either of these events is a buildup of circulating levels of ammonium ion. In the absence of an aerobic oxidative phosphorylation and TCA cycle activity, irreparable cell damage and neural cell death can ensue.


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Notes to remember

Growth patterns of starved individuals, especially the children slowed down. The decrease in water intake associated with food deprivation can lead to an increase of the haematocrit. There is a neuronal noradrenergic activity during acute and chronic starvation.


Food deprivation can be expressed as a reduction in the noradregenic turnover in the A6 cell group after acute starvation. Food deprivation increased the activity of the sympathetic nervous system of the heart and created a sympathetic activation of the kidneys. Food deprivation causes stress.




Bilsborough, S. & Mann, N. (2006). A review of issues of dietary protein intake in humans. Int J Sport Nutr Exerc Metab, 16(2), pp. 129-52.

Zeratsky, K. (n.d.). Are protein diets safe for weight loss? Mayo Clinic.


More information about urea



More information about food deprivation and starvation